Autologous bone grafts generally demonstrate the greatest regenerative potential for tissue repair but are hampered by limited availability and significant complications at the donor site.
Load-bearing cortical bridging was achieved in all animals, with increased bone volume observed in sheep that received osteoinductive scaffolds compared to sheep that received an rhBMP-2-eluting collagen sponge alone.īone grafts are often required to reconstruct segmental bone defects caused by trauma or disease 1, 2.
Bone regeneration after 24 weeks was evaluated by micro-computed tomography, mechanical testing, and histological characterization. We here demonstrate that an osteoinductive scaffold, fabricated by combining a 3D printed rigid polymer/ceramic composite scaffold with an rhBMP-2-eluting collagen sponge can treat extremely large-scale segmental defects in a pilot feasibility study using a new sheep metatarsus fracture model stabilized with an intramedullary nail. The delivery of rhBMP-2 may even enable engineered synthetic scaffolds to be used in place of autologous bone grafts for the treatment of critical size defects, eliminating risks associated with autologous tissue harvest.
Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and enhance the healing efficacy of bone grafts. The Iron Bridge project is set to deliver 22 Mt/y of high-grade magnetite concentrate product, with first production scheduled for the upcoming March quarter.Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Terry Wilson, Bugarrba Board Member, said: “Bugarrba are excited to secure another important contract for the Njamal people and are looking forward to working with Iron Bridge Operations located on the traditional lands of the Njamal people.”ĭavid Macgeorge, SRG Global Managing Director, added: “SRG is tremendously proud of our Bugarrba joint venture, seeing its continued success and contribution to Aboriginal people, and working with Iron Bridge Operations, on what is such an innovative project for Western Australia.” Bugarrba’s vision is to provide meaningful and sustainable employment opportunities to its people and Aboriginal people more broadly. The traditional land of the Njamal people covers 42,000 sq.km within the Pilbara, with its name meaning ‘Country’ in the Njamal language. The contract, valued at circa-A$40 million ($26 million) is expected to commence early in 2023.īugarrba is a joint venture with members of the Njamal People and SRG Global. Its new magnetite project in Western Australia. The five-year term contract with Iron Bridge, an unincorporated joint venture between Fortescue Metals Group (Fortescue) subsidiary FMG Iron Bridge and Formosa Steel IB, is a master agreement for maintenance and shutdown services to provide engineered scaffold services across SRG Global Ltd says its Aboriginal Joint Venture, Bugarrba, has been awarded a five-year term contract with Iron Bridge Operations in the Pilbara of Western Australia.
0 kommentar(er)
